Anti-CD2 Monoclonal Antibodies Prevent the Induction of Experimental Autoimmune Myocarditis.

Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: evidence for an IL-4 requirement.

Anti-CD2 mAb plus anti-CD3 mAb induce alloantigen specific tolerance. We sought to determine whether Th2 cytokines are involved in the induction of tolerance in this model. Addition of anti-IL-4 mAb or anti-IL-10 mAb to anti-CD2 plus anti-CD3 treatment abrogated tolerance and resulted in graft survivals of 26+/-4 and 25+/-5 days, respectively. Splenocytes from the anti-IL-4 mAb and anti-IL-10 g...

Monoclonal Antibodies: Evidence for an IL-4 Tolerance Induction by Anti-CD2 Plus Anti-CD3

Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies

Rat T cells and thymocytes were induced to proliferate by a pair of mAbs, MRC OX-54 and MRC OX-55, directed against rat CD2. Accessory cells were required but their role was not simply for crosslinking of the two mAbs, as neither MRC OX-54 nor MRC OX-55 alone, in the presence of a crosslinking second antibody, caused T cell mitogenesis. Nor could the phorbol ester PMA replace either antibody. T...

Mutational analysis of the epitopes recognized by anti-(rat CD2) and anti-(rat CD48) monoclonal antibodies.

I88 problems such as developmental delay, ovarian dysfunction and speech abnormalities persist. This suggests that the alternative pathway for the formation of UDP-galactose by UDP-glucose-4-epimerase for galactosylation is inadequate in certain cells or in the fetus. The structure of the serum disialotransferrin and other glycoproteins in untreated and treated galactosaemia patients is under i...

Captopril prevents experimental autoimmune myocarditis.

Captopril, an angiotensin-converting enzyme inhibitor, is widely used in the treatment of a variety of cardiomyopathies, but its effect on autoimmune myocarditis has not been addressed experimentally. We investigated the effect of captopril on myosin-induced experimental autoimmune myocarditis. A/J mice, immunized with syngeneic cardiac myosin, were given 75 mg/L of captopril in their drinking ...